結構式
CAS: 367-21-5
分子式: C6H5ClFN
分子量: 145.56
中文名稱: 4-氟-3-氯苯胺
3-氯-4-氟苯胺
氟氯苯胺
英文名稱: 3-chloro-4-fluoro-Benzenamine
3-Chloro-4-fluoroaniline
3-chloro-4-fluoro-benzenamin
Fluorochloroaniline
3-Chloro-4-fluorobenzenamine
性質描述: 白色結晶粉末。熔點44℃（45-47℃），沸點227-228℃，閃點149℃。
質量標準
外觀 類白色晶體或粉末
含量 ≥99.8%（氣相色譜法）
水分 ≤0.2%
熔點 42-44
沸點 238-240
閃點 >110℃
用途: 藥物合成氟哌酸（諾氟沙星）的重要中間體，用于生產諾氟沙星(氟哌酸、淋克小星、力醇羅、淋沙星、淋克星)，若氯化脫硝制得2,4-二氯氟苯，經進一步合成可制得環丙沙星。
其它信息：
【Product Name】3-Chloro-4-fluoroaniline
【Synonyms】3-氯-4-氟苯胺
【CAS】367-21-5
【Formula】C6H5ClFN
【Molecular Weight】145.56
【EINECS】206-682-8
【Beilstein/Gmelin】1562786
【Beilstein Reference】4-12-00-01239
【EC Class】harmful
Physical and Chemical Properties
【Appearance】Black to dark-purple powder.
【Solubility in water】10 g/L (20 C)
【Melting Point】41 - 44
【Boiling Point】230
【Density】1.226 g/cm3 (20 C)
【Partition Coefficient】2.12
First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.
【Handling】Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air.
Hazards Identification
【Inhalation】May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression and asphixiation.
【Skin】May cause skin irritation.
【Eyes】May cause eye irritation.
【Ingestion】May cause irritation of the digestive tract. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis, convulsions, and death. May cause central nervous system depression.
【Hazards】Contact with metals may evolve flammable hydrogen gas.
【EC Risk Phrase】R 23/24/25 33
【EC Safety Phrase】S 28 36/37 45
【UN (DOT)】2811
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death.
Fire Fighting Measures
【Flash Point】114
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use water spray to cool fire-exposed containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
【Fire Potential】Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.
Stability and Reactivity
【Disposal Code】9
【Incompatibilities】Air, acids, acid chlorides, acid anhydrides, chloroformates, oxidizing agents.
【Stability】Stable under normal temperatures and pressures.
【Decomposition】Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
【UN Number】2811
【Hazard Class】6.1
【Packing Group】I; II; III
【HS Code】2921 42 10
