結構式
CAS: 140-75-0
分子式: C7H8FN
分子量: 125.15
中文名稱: 對氟芐胺
對氟苯甲胺
4-氟苯甲胺
英文名稱: 4-fluoro-benzenemethanamin
4-fluorobenzylamine
性質描述: 無色清澈液體，相對密度（20/4℃）1.102，折光率（nD20）1.512。密度1.09，沸點183℃ ，閃點66℃
用途: 抗過敏藥物阿司咪唑，鎮痛藥Flupirine的中間體。
其它信息：
Product Identification
【Product Name】4-Fluorobenzylamine 對氟芐胺
【Synonyms】p-Fluorobenzylamine
【CAS】140-75-0
【Formula】C7H8FN
【Molecular Weight】125.15
【EINECS】205-430-4
【Beilstein/Gmelin】636501
【Beilstein Reference】4-12-00-02358
【EC Class】irritant
Physical and Chemical Properties
【Appearance】Clear, colorless liquid.
【Solubility in water】Very soluble
【Boiling Point】183
【Density】1.09 g/cm3
【pKa/pKb】9.31 (pKa)
【Vapor Density】4.32
【Refractive Index】1.51 (20 C)
First Aid Measures
【Ingestion】Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
【Inhalation】Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
【Skin】Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
【Eyes】Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).
Handling and Storage
【Storage】Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Hazards Identification
【Inhalation】May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Inhalation at high concentrations may cause CNS depression and asphixiation.
【Skin】Causes skin burns. May cause irritation and dermatitis. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
【Eyes】Causes eye burns. May cause chemical conjunctivitis and corneal damage.
【Ingestion】May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May cause systemic effects.
【Hazards】Contact with metals may evolve flammable hydrogen gas.
【EC Risk Phrase】R 34
【EC Safety Phrase】S 26 36/37/39 45
【UN (DOT)】1719
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Effects may be delayed.
Fire Fighting Measures
【Flash Point】66
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.
【Fire Potential】Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Accidental Release Measures
【Small spills/leaks】Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Stability and Reactivity
【Stability】Stable under normal temperatures and pressures.
【Incompatibilities】Strong acids, strong oxidizing agents, acid anhydrides, acid chlorides.
【Decomposition】Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride, nitrogen.
【Combustion Products】Fire may produce irritating, corrosive and/or toxic gases.
Transport Information
【UN Number】1719
【Hazard Class】8
【Packing Group】II; III
【HS Code】2921 49 80
