用途: 醫(yī)藥中間體，用于抗過(guò)敏藥物氯雷他定的合成。
其它信息：
Product Identification
【Product Name】3-Methylpyridine-2-carbonitrile
【Synonyms】2-氰基-3-甲基吡啶
【CAS】20970-75-6
【Formula】C7H6N2
【Molecular Weight】118.13
【EINECS】244-131-3
【Beilstein/Gmelin】112001
【Beilstein Reference】5-22-02-00324
Physical and Chemical Properties
【Appearance】Solid.
【Melting Point】87-90℃
【Boiling Point】139-142℃ (38 torr)
First Aid Measures
【Ingestion】get medical aid. Wash mouth out with water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage
【Storage】Store in a cool, dry place. Store in a tightly closed container.
【Handling】Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.
Hazards Identification
【Ingestion】May cause irritation of the digestive tract. May be harmful if swallowed.
【Inhalation】Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May be harmful if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
【Skin】Causes skin irritation. May be harmful if absorbed through the skin.
【Eyes】Causes eye irritation.
【EC Risk Phrase】R 20/21/22
【EC Safety Phrase】S 22 36/37
【UN (DOT)】2811
Exposure Controls/Personal Protection
【Personal Protection】Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Fire Fighting Measures
【Flash Point】115℃
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use foam, dry chemical, or carbon dioxide.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material and place into a suitable disposal container.
Stability and Reactivity
【Stability】No data.
【Incompatibilities】Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides.
【Decomposition】Nitrogen oxides, carbon monoxide, carbon dioxide.
Transport Information
【UN Number】2811
