結(jié)構(gòu)式
CAS: 524-38-9
分子式: C8H5NO3
分子量: 163.13
中文名稱: N-羥基鄰苯二甲酰亞胺
N-羥基酞酰亞胺
英文名稱: n-hydroxy-phthalimid
2-hydroxy-1h-isoindole-3(2h)-dione
2-hydroxyphthalimide
性質(zhì)描述: 淡黃色結(jié)晶粉末，熔點(diǎn) 233-235℃
質(zhì)量指標(biāo)
含量 98.0%
水份 ≤0.5％
熔點(diǎn) >230.0℃
用途: 阿米卡星等藥物中間體。
其它信息：
Product Identification
【Product Name】N-Hydroxyphthalimide N-羥基鄰苯二甲酰亞胺(NOP)
【Synonyms】2-Hydroxyisoindole-1,3-dione；2-Hydroxyphthalimide
【CAS】524-38-9
【Formula】C8H5NO3
【Molecular Weight】163.13
【EINECS】208-358-1
【RTECS】TI5200000
【RTECS Class】Other
【Merck】13,4864
【Beilstein/Gmelin】131208
【Beilstein Reference】5-21-11-00100
Physical and Chemical Properties
【Appearance】White to off-white crystalline powder.
【Solubility in water】Slightly soluble
【Melting Point】230 - 233
【Boiling Point】412
【Density】1.58 g/cm3
【Partition Coefficient】.92
【Refractive Index】1.522
First Aid Measures
【Ingestion】Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
【Inhalation】Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
【Skin】Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and Storage
【Storage】Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.
Hazards Identification
【Inhalation】Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.
【Skin】Causes skin irritation. May be harmful if absorbed through the skin.
【Eyes】Causes eye irritation. May cause chemical conjunctivitis.
【Ingestion】May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
【EC Risk Phrase】R 36/37/38
【EC Safety Phrase】S 26 36
Exposure Controls/Personal Protection
【Personal Protection】Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】Effects may be delayed.
Fire Fighting Measures
【Fire Fighting】Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Accidental Release Measures
【Small spills/leaks】Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability and Reactivity
【Disposal Code】3
【Incompatibilities】Oxidizing agents.
【Stability】Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Transport Information Back to Contents
【HS Code】2925 19 95
